Official:MacOS Readme

Hardware/Software Minimum Requirements:
PowerPC or Intel-based Mac, although using the dual core Intel systems will give a much better experience.

512 Mb in addition to system memory requirements – the more the better. 1-2 Gb or more is strongly recommended for larger or more complex documents.

Before Installing Scribus

 * Install Ghostscript for Mac OSX – Ghostscript 8.60+ or newer is recommended. This is important for EPS, PS import and printing. You may also install this via MacPorts or Fink. The end result is the same.
 * This is beta software which is undergoing many code changes daily. While it is fairly stable and usable, caution is advised. It is not recommended yet for production use.

Installing

 * Simply download the Mac OSX dmg format file from Sourceforge, open it and drag the Scribus icon to the location of your choice. The dmg Finder window offers the default system Application directory. From there you may click on the icon and run Scribus.
 * The first launch of Scribus or when a new user launches Scribus will be much longer than usual. This is because Scribus is creating a cache file of your fonts. Later re-starts will be much quicker.

Additional Software

 * As of version 1.3.5, Scribus provides a new type of frame, called Render Frame. It allows the use of other programs to render their outpout in a Scribus document. To take full advantage of this feature, you need to install these programs. By default, Scribus is preconfigured to use LaTeX, Lilypond, POV-Ray, Graphviz, and Gnuplot.

Console Mode for Diagnostics
There is a second way to launch Scribus: Console Mode. If you open Console.app from the Applications Utilities folder, you are able to see the output of Scribus on startup. This will give you information on the fonts discovered on startup, and list any issues found while starting.